| DOI | Trouver le DOI : https://doi.org/10.1016/S0959-8049(16)32910-0 |
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| Auteur | Rechercher : O'connor-mccourt, M.; Rechercher : Lenferink, A.1; Rechercher : Zwaagstra, J.1; Rechercher : Sulea, T.1; Rechercher : Weeratna, R.1; Rechercher : Maleki, S.; Rechercher : Baardsnes, J.1; Rechercher : Collins, C.1; Rechercher : Cantin, C.1; Rechercher : Durocher, Y.1; Rechercher : Singh, R.1; Rechercher : Figueredo, R.; Rechercher : Krishnan, L.1; Rechercher : Koropatnick, J.; Rechercher : Tikhomirov, I. |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Résumé | In efficacy studies using the syngeneic 4T1 TNBC model, AVID200 was shown to promote significant T-cell infiltration into tumors. This infiltration resulted in reduced primary tumor growth as well as significant reductions in metastatic lesions. Additionally, ex vivo studies revealed that AVID200 treatment decreased T-cell apoptosis, promoted T-cell proliferation in response to tumor cell lysates in the presence of dendritic cells, as well as increased the capacity of T-cells to specifically lyse 4T1 tumor cells. The novel computational design of AVID200 results in a trap with low pM in vitro neutralization potency for TGF-b 1 and 3. Additionally, AVID200 markedly promotes the “T-cell-inflamed” tumor state in vivo. Combination studies with immune checkpoint inhibitors will be presented. |
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| Date de publication | 2016-12 |
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| Dans | |
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| Note | 28 EORTC – NCI – AACR Symposium on Molecular Targets and Cancer Therapeutics Wednesday 29 November 2016: Poster Sessions: Immunotherapy: Poster (Board P144) |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23001208 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | fc21b4ce-4778-42e5-9a89-dade828fc71b |
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| Enregistrement créé | 2017-01-05 |
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| Enregistrement modifié | 2020-03-16 |
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