DOI | Trouver le DOI : https://doi.org/10.1002/pmic.201500169 |
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Auteur | Rechercher : Nasheri, Neda1; Rechercher : Ning, Zhibin; Rechercher : Figeys, Daniel; Rechercher : Yao, Shao; Rechercher : Goto, Natalie K.; Rechercher : Pezacki, John Paul2 |
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Affiliation | - Conseil national de recherches du Canada
- Conseil national de recherches du Canada. Dispositifs médicaux
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Format | Texte, Article |
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Sujet | proteasome; ubiquitin; virus protein; chronic hepatitis C; down regulation; Hepatitis C virus; protein expression; protein subunit; quantitative analysis; virus replication |
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Résumé | Hepatitis C virus (HCV) infection often leads to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The stability of the HCV proteins is controlled by ubiquitin-dependent and ubiquitin-independent proteasome pathways. Many viruses modulate proteasome function for their propagation. To examine the interrelationship between HCV and the proteasome pathways we employed a quantitative activity-based protein profiling method. Using this approach we were able to quantify the changes in the activity of several proteasome subunits and found that proteasome activity is drastically reduced by HCV replication. The results imply a link between the direct downregulation of the activity of this pathway and chronic HCV infection. |
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Date de publication | 2015-10-08 |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Oui |
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Numéro NPARC | 21277371 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | da43b367-fe63-43ea-9274-105f77de416e |
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Enregistrement créé | 2016-03-09 |
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Enregistrement modifié | 2020-04-22 |
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