Development of an anti-vascular cell adhesion protein-1 aptamer for molecular imaging and inflammation detection in transgenic mouse model of Alzheimer's disease

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DOIResolve DOI: http://doi.org/10.1166/jbn.2015.2154
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TypeArticle
Journal titleJournal of Biomedical Nanotechnology
ISSN1550-7033
Volume11
Issue12
Pages22642274; # of pages: 11
SubjectCell adhesion; Cells; Cytology; Diagnosis; Dissociation; Endothelial cells; Infrared devices; Mammals; Molecules; Neurodegenerative diseases; Pathology; Alzheimer's disease; Aptamers; Near-infrared fluorescence imaging; Therapeutic monitoring; Vascular cell adhesion; VCAM-1; Molecular imaging; amyloid beta protein; aptamer; cyanine dye 5 11R6; fluorescein; fluorescent dye; single stranded DNA; vascular cell adhesion molecule 1; animal experiment; animal model; animal tissue; cerebellum; DNA library; DNA sequence; electrophoretic mobility; fluorescence imaging; fluorescence microscopy; gel mobility shift assay; human; human cell; in vitro selection; in vivo study; mouse; nervous system inflammation; nonhuman; protein targeting; umbilical vein endothelial cell; disease model; fluorescence imaging; genetics; inflammation; metabolism; molecular imaging; nucleotide sequence; transgenic mouse; Aptamers, Nucleotide; Base Sequence; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Mice, Transgenic; Optical Imaging
Abstract
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PublisherAmerican Scientific Publishers
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Human Health Therapeutics
Peer reviewedYes
NPARC number21277338
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Record identifierc5414c9b-5302-4caa-a514-b2759c8ba8a1
Record created2016-03-09
Record modified2016-05-09
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