Asymmetric mutations in the tetrameric R67 dihydrofolate reductase reveal high tolerance to active-site substitutions

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DOIResolve DOI: http://doi.org/10.1002/pro.2602
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TypeArticle
Journal titleProtein Science
ISSN0961-8368
Volume24
Issue4
Pages495507
SubjectTrimethoprim resistance; Combinatorial mutations; Thermostability; Active site engineering; Homotetramer
Abstract
Publication date
PublisherWiley
LanguageEnglish
AffiliationAquatic and Crop Resource Development; National Research Council Canada
Peer reviewedYes
NPARC number23000250
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Record identifier7a9f0354-55fa-47d8-bdf9-e0b9897505dc
Record created2016-06-28
Record modified2016-06-28
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