| Auteur | Rechercher : Saito, K.; Rechercher : Yajima, T.; Rechercher : Kumabe, S.; Rechercher : Doi, T.; Rechercher : Yamada, H.; Rechercher : Sad, Subash; Rechercher : Shen, H.; Rechercher : Yoshikai, Y. |
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| Format | Texte, Article |
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| Sujet | Bacillus; bacterial; cell; CELLS; INFECTION; Mice; POTENTIAL; PROTECTION; Role |
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| Résumé | To investigate the potential role of endogenous IL-15 in mycobacterial infection, we examined protective immunity in IL-15-deficient (IL-15(-/-)) mice after infection with Mycobacterium bovis bacillus Calmette-Guerin (BCG) or recombinant OVA-expressing BCG (rBCG-OVA). IL-15(-/-) mice exhibited an impaired protection in the lung on day 120 after BCG infection as assessed by bacterial growth. CD4(+) Th1 response capable of producing IFN-gamma was normally detected in spleen and lung of IL-15(-/-) mice on day 120 after infection. Although Ag-specific CD8 responses capable of producing IFN-gamma and exhibiting cytotoxic activity were detected in the lung on day 21 after infection with rBCG-OVA, the responses were severely impaired on days 70 and 120 in IL-15(-/-) mice. The degree of proliferation of Ag-specific CD8(+) T cells in IL-15(-/-) mice was similar to that in wild-type mice during the course of infection with rBCG-OVA, whereas sensitivity to apoptosis of Ag-specific CD8(+) T cells significantly increased in IL-15(-/-) mice. These results suggest that IL-15 plays an important role in the development of long-lasting protective immunity to BCG infection via sustaining CD8 responses in the lung |
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| Date de publication | 2006-02-15 |
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| Dans | |
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| Langue | anglais |
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| Numéro du CNRC | SAITO2006 |
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| Numéro NPARC | 9361760 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | f83ae1bf-5ed1-46ad-a16e-54602358052d |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-04-22 |
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