Téléchargement | - Voir le manuscrit accepté : Predicting pharmaceutical manufacturing changes using molecular laser-induced breakdown spectroscopy and chemometrics (PDF, 157 Kio)
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Auteur | Rechercher : Doucet, François R.1; Rechercher : Faustino, Patrick J.; Rechercher : Tourigny, Martine; Rechercher : Lyon, Robbe C.; Rechercher : Sabsabi, Mohamad1 |
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Affiliation | - Conseil national de recherches du Canada. Institut des matériaux industriels du CNRC
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Format | Texte, Article |
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Conférence | IFPAC 2008, January 27-30, 2008, Baltimore, Maryland, USA |
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Résumé | In many pharmaceutical manufacturing applications, Laser Induced Breakdown Spectroscopy (LIBS) makes possible at-line rapid measurements of many formulation ingredients as well as the possibility of stand-off analysis, in-situ, in-line and on line process monitoring. These capabilities make LIBS an attractive PAT sensor technology that can be introduced virtually everywhere in the pharmaceutical manufacturing process. Molecular Laser-Induced Breakdown Spectroscopy (MO-LIBS) uses the molecular band emission of small diatomic fragments and chemometrics to establish predictive model that allow quantitative measurements. This innovative approach allows a complete simultaneous formulation ingredients analysis as well as the prediction of pharmaceutical manufacturing changes. The results obtained in this work highlight the potential for MO-LIBS to be more widely applied to process monitoring and quality control of pharmaceutical products. |
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Date de publication | 2008-01-27 |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Non |
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Numéro du CNRC | NRCC 54242 |
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Numéro NPARC | 18335899 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | f360f69a-e20a-451d-b679-4980084943a0 |
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Enregistrement créé | 2011-07-29 |
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Enregistrement modifié | 2020-08-12 |
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