Influence of water activity on the enantioselective esterification of (R,S)-ibuprofen by crosslinked crystals of <I>Candida antarctica</I> lipase B in organic solvent media

DOI	Trouver le DOI : https://doi.org/10.1002/bit.10051
Auteur	Rechercher : Pepin, Pierre; Rechercher : Lortie, Robert¹
Affiliation	Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
Format	Texte, Article
Résumé	The lipase B from was purified from a commercial source and crystalized. The microcrystals were crosslinked using glutaraldehyde. The crosslinked crystals were then used to catalyze the esterification of ()-ibuprofen with dodecanol in octane at various water activities. As for the commercial preparation immobilized on acrylic resin, Novozym 435, low water activities foster better enantioselectivity, and the maximum reaction rates are obtained for W = 0.1. � 2001 John Wiley & Sons, Inc. Biotechnol Bioeng 75: 559-562, 2001.
Date de publication	2001
Dans	Biotechnology and Bioengineering 75, nº 5 (2001) : 559–562.
Numéro NPARC	12327007
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	e8be2d6d-d02b-403c-8e90-c0631d6890fa
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-03-27