| Téléchargement | - Voir le manuscrit accepté : Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2 (PDF, 717 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1111/j.1365-2567.2010.03296.x |
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| Auteur | Rechercher : Tancowny, Brian P.; Rechercher : Karpov, Victor; Rechercher : Schleimer, Robert P; Rechercher : Kulka, Marianna |
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| Format | Texte, Article |
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| Sujet | chemokines; immunoglobulin E; mast cells; neuropeptides; substance P; vasoactive intestinal peptide |
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| Résumé | Substance P (SP) is a neuropeptide with neuroimmunoregulatory activity that may play a role in susceptibility to infection. Human mast cells which are important in innate immune responses, were analysed for their responses to pathogen-associated molecules via Toll-like receptors (TLRs in the presence of SP. Human cultured mast cells (LAD2) were activated by SP and TLR ligands including lipopolysaccharide (LPS), Pam3CysSer- Lys4 (Pam3CSK4) and lipoteichoic acid (LTA), and mast cell leukotriene and chemokine production was assessed by enzyme-linked immunosorbent assay (ELISA) and gene expression by quantitative PCR (qPCR). |
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| Date de publication | 2010-03-30 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 17326690 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | d96b6a23-eab8-424e-95e2-261355ff706a |
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| Enregistrement créé | 2011-03-18 |
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| Enregistrement modifié | 2020-04-17 |
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