| Téléchargement | - Voir le manuscrit accepté : PEG-covered ultra-small Gd₂O₃ nanoparticles for positive contrast at 1.5T MR clinical scanning (PDF, 907 Kio)
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| DOI | Trouver le DOI : https://doi.org/10.1088/0957-4484/18/39/395501 |
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| Auteur | Rechercher : Fortin, Marc-André; Rechercher : Petoral Jr., Rodrigo M.; Rechercher : Söderlind, Fredrik; Rechercher : Klasson, A.; Rechercher : Engstöm, Maria; Rechercher : Veres, Teodor1; Rechercher : Käll, Per-Olod; Rechercher : Uvdal, Kajsa |
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| Affiliation | - Conseil national de recherches du Canada. Institut des matériaux industriels du CNRC
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| Format | Texte, Article |
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| Résumé | The size distribution and magnetic properties of ultra-small gadolinium oxide crystals (US-Gd₂O₃) were studied, and the impact of polyethylene glycol capping on the relaxivity constants (r₁, r₂) and signal intensity with this contrast agent was investigated. Size distribution and magnetic properties of US-Gd₂O₃ nanocrystals were measured with a TEM and PPMS magnetometer. For relaxation studies, diethylene glycol (DEG)-capped US-Gd₂O₃ nanocrystals were reacted with PEG-silane (MW 5000). Suspensions were adequately dialyzed in water to eliminate traces of Gd³⁺ and surfactants. The particle hydrodynamic radius was measured with dynamic light scattering (DLS) and the proton relaxation times were measured with a 1.5 T MRI scanner. Parallel studies were performed with DEG–Gd₂O₃ and PEG-silane–SPGO (Gd₂O₃, < 40 nm diameter). The small and narrow size distribution of US-Gd₂O₃ was confirmed with TEM (∼3 nm) and DLS. PEG-silane–US-Gd₂O₃ relaxation parameters were twice as high as for Gd–DTPA and the r₂/r₁ ratio was 1.4. PEG-silane–SPGO gave low r₁ relaxivities and high r₂/r₁ ratios, less compatible with positive contrast agent requirements. Higher r₁ were obtained with PEG-silane in comparison to DEG–Gd₂O₃. Treatment of DEG–US-Gd₂O₃ with PEG-silane provides enhanced relaxivity while preventing aggregation of the oxide cores. This study confirms that PEG-covered Gd₂O₃ nanoparticles can be used for positively contrasted MR applications requiring stability, biocompatible coatings and nanocrystal functionalization. |
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| Date de publication | 2007-09-04 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRCC 53688 |
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| Numéro NPARC | 15859840 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | d204616c-f9e6-4780-bb1a-d767a762af42 |
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| Enregistrement créé | 2010-07-23 |
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| Enregistrement modifié | 2020-05-10 |
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