Enantioselective Esterification of Racemic Ibuprofen in Solvent Media under Reduced Pressure

DOI	Trouver le DOI : https://doi.org/10.1002/(SICI)1097-4660(199706)69:2<266::AID-JCTB698>3.0.CO;2-6
Auteur	Rechercher : Roure, Frederic; Rechercher : Ducret, Amélie¹; Rechercher : Trani, Michael¹; Rechercher : Lortie, Robert¹
Affiliation	Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
Format	Texte, Article
Résumé	The enantioselective esterification of (R,S)-ibuprofen has been performed with Novozym 435TM in solvent media under reduced pressure. The nature of the solvent affects the activity and enantioselectivity of the lipase. High esterification rates are obtained in solvents having high hydrophobicity (log P>4). On the other hand, the best enantioselectivity is obtained with solvents having low hydrophobicity (log P<3). This particular enantioselectivity trend is observed within the individual solvent families investigated (alkanes, ethers and aromatics). � Canadian Crown Copyright 1997
Date de publication	1997
Dans	Journal of Chemical Technology & Biotechnology 69, nº 2 (1997) : 266–270.
Numéro NPARC	12327710
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	ca51be83-23df-4cd2-a8f6-7094529123a7
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-03-20