Téléchargement | - Voir le manuscrit accepté : Single-Domain Antibody Bioconjugated Near-IR Quantum Dots for Targeted Cellular Imaging of Pancreatic Cancer (PDF, 1019 Kio)
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DOI | Trouver le DOI : https://doi.org/10.1166/jnn.2011.4167 |
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Auteur | Rechercher : Zaman, Md. Badruz1; Rechercher : Baral, Toya Nath1; Rechercher : Jakubek, Zygmunt J.2; Rechercher : Zhang, Jianbing1; Rechercher : Wu, Xiaohua3; Rechercher : Lai, Edward; Rechercher : Whitfield, Dennis1; Rechercher : Yu, Kui2 |
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Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
- Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
- Conseil national de recherches du Canada. Institut des sciences des microstructures du CNRC
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Format | Texte, Article |
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Sujet | Photoluminescent Near-IR Quantum Dots; Single-Domain Antibody; In Vitro Targeted Cellular Imaging; Colloidal Nanocrystals; Pancreatic and Breast Cancer |
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Résumé | Successful targeted imaging of BxPC3 human pancreatic cancer cells is feasible with near-IR CdTeSe/CdS quantum dots (QDs) functionalized with single-domain antibody (sdAb) 2A3. For specific targeting, sdAbs are superior to conventional antibodies, especially in terms of stability, aggregation, and production cost. The bright CdTeSe/CdS QDs were synthesized to emit in the diagnostic window of 650-900 nm with a narrow emission band. 2A3 was derived from llama and is small in size of ∼13 kDa, but with fully-functional recognition to the target carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a possible biomarker as a therapeutic target of pancreatic cancer. For compelling imaging, optical may be the most sensible among the various imaging modalities, regarding the sensitivity and cost. This first report on sdAb-conjugated near-IR QDs with high signal to background sensitivity for targeted cellular imaging brings insights into the development of optical molecular imaging for early stage cancer diagnosis. |
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Date de publication | 2011-01-01 |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Oui |
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Numéro NPARC | 17652983 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | bc8a1ff6-0b8b-4268-a243-69ff2cef5943 |
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Enregistrement créé | 2011-03-31 |
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Enregistrement modifié | 2020-04-21 |
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