| DOI | Trouver le DOI : https://doi.org/10.1016/0960-894X(96)00092-3 |
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| Auteur | Rechercher : Schneider, H.1; Rechercher : Fiander, H.1; Rechercher : Harrison, K.A.2; Rechercher : Watson, M.2; Rechercher : Burton, G. W.2; Rechercher : Arya, P.2 |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
- Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
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| Format | Texte, Article |
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| Résumé | The effectiveness of analogs of lithocholic acid and other bile acids in inhibiting glucuronosyltransferase activity in a colon cancer cell line was measured in order to identify structural features critical for inhibition of the enzyme. Analogs of lithocholic acid with modifications of the side chain (2-7) were synthesized, in part, to study their inhibitory effects on glucuronosyltransferase activity. Bishomolithocholic acid (4) was synthesized from the iodo derivative (9) by a free radical Michael type reaction using tris(trimethylsilyl)silane as a free radical mediator. The effectiveness of analogs of lithocholic acid and other bile acids on glucuronosyltransferase activity in a colon cancer cell line was measured in order to identify structural features critical for the inhibition. Analogs of lithocholic acid (2-7) were synthesized with modifications of the side chain. Bishomolithocholic acid (4) was synthesized from the iodo derivative (9) by a free radical Michael type reaction-using tris(trimethylsilyl)silane as a free radical mediator. |
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| Date de publication | 1996-03-19 |
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| Dans | |
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| Langue | anglais |
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| Numéro du CNRC | SCHNEIDER1996 |
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| Numéro NPARC | 12338704 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | bc7177ba-b4fa-4a7e-b561-457c83bc8a42 |
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| Enregistrement créé | 2009-09-10 |
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| Enregistrement modifié | 2020-03-20 |
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