DOI | Trouver le DOI : https://doi.org/10.1007/978-94-011-0371-8_221 |
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Auteur | Rechercher : Jackson, Michael1; Rechercher : Sowa, Michael G.1; Rechercher : Liu, Kan-zhi1; Rechercher : Ju, Haisong; Rechercher : Dixon, Ian M. C.; Rechercher : Mantsch, Henry H.1 |
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Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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Format | Texte, Chapitre de livre |
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Conférence | 6th European Conference on the Spectroscopy of Biological Molecules, September 3–8, 1995, Villeneuve d’Ascq, France |
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Résumé | Heart disease remains the leading cause of death in the industrialised world, accounting for 50% of all deaths in North America. Overwhelmingly the most important form of heart disease is ischaemic heart disease (IHD), which usually (90% of cases) takes the form of a myocardial infarction (MI) as a result of artherosclerosis (AS). Fissuring of an AS plaque results in thrombosis, which can cause blockage of the coronary arteries leading to ischaemia. Prolonged ischaemia (20 minutes) leads to irreversible damage to the heart. If the initial ischaemic event is survived, significant modifications of the extracellular matrix (ECM) of the heart become apparent after about 7 days, leading to pronounced scar formation after 6–8 weeks. As the ECM plays an important role in maintaining the mechanical and electrical properties of the heart, modifications of the ECM have pronounced pathological effects, resulting in reduced compliance of the left ventricle and potentially fatal arrhythmias (due to modification of conduction properties of the tissues). |
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Date de publication | 1995 |
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Dans | |
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Langue | anglais |
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Numéro du CNRC | NRC-IBD-419 |
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Numéro NPARC | 9742702 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | adef5fbd-e3ea-40e3-8c08-8d8d63702a59 |
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Enregistrement créé | 2009-07-17 |
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Enregistrement modifié | 2020-06-11 |
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