Téléchargement | - Voir le manuscrit accepté : Chemogenomic profiling predicts antifungal synergies (PDF, 1.5 Mio)
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DOI | Trouver le DOI : https://doi.org/10.1038/msb.2009.95 |
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Auteur | Rechercher : Jansen, Gregor; Rechercher : Lee, Anna Y.; Rechercher : Epp, Elias1; Rechercher : Fredette, Amélie; Rechercher : Surprenant, Jamie; Rechercher : Harcus, Doreen1; Rechercher : Scott, Michelle; Rechercher : Tan, Elaine; Rechercher : Nishimura, Tamiko; Rechercher : Whiteway, Malcolm1; Rechercher : Hallett, Michael; Rechercher : Thomas, David Y. |
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Affiliation | - Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
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Format | Texte, Article |
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Sujet | antifungal; chemical genomics; drug profiling; synergy predictor |
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Résumé | Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinformatics-driven approach that efficiently predicts compound synergy for such combinatorial therapies. The approach uses chemogenomic profiles in order to identify compound profiles that have a statistically significant degree of similarity to a fluconazole profile. The compounds identified were then experimentally verified to be synergistic with fluconazole and with each other, in both Saccharomyces cerevisiae and the fungal pathogen Candida albicans. Our method is therefore capable of accurately predicting compound synergy to aid the development of combinatorial antifungal therapies. |
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Date de publication | 2009-12-22 |
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Dans | |
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Langue | anglais |
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Publications évaluées par des pairs | Oui |
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Numéro du CNRC | NRCC 49513 |
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Numéro NPARC | 18397755 |
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Exporter la notice | Exporter en format RIS |
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Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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Identificateur de l’enregistrement | a46c37fc-6d2f-4310-baa3-b7863cb0ecd0 |
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Enregistrement créé | 2012-03-06 |
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Enregistrement modifié | 2020-04-16 |
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