| DOI | Trouver le DOI : https://doi.org/10.1093/glycob/cwv037 |
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| Auteur | Rechercher : Haji-Ghassemi, O.; Rechercher : Blackler, R.J.; Rechercher : Young, N.M.1; Rechercher : Evans, S.V. |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | anti-carbohydrate antibodies; carbohydrate recognition; Chlamydia; HIV-1 gp120; lipopolysaccharide; monoclonal antibody; X-ray crystal structures |
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| Résumé | Carbohydrate antigens are valuable as components of vaccines for bacterial infectious agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics against cancer. The crystal structures of anti-carbohydrate antibodies in complex with antigen reveal the key features of antigen recognition and provide information that can guide the design of vaccines, particularly synthetic ones. This review summarizes structural features of anti-carbohydrate antibodies to over 20 antigens, based on six categories of glyco-antigen: (i) the glycan shield of HIV glycoproteins; (ii) tumor epitopes; (iii) glycolipids and blood group A antigen; (iv) internal epitopes of bacterial lipopolysaccharides; (v) terminal epitopes on polysaccharides and oligosaccharides, including a group of antibodies to Kdo-containing Chlamydia epitopes; and (vi) linear homopolysaccharides. |
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| Date de publication | 2015 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21277037 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 9f334212-7476-4082-a512-7812740f9d70 |
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| Enregistrement créé | 2015-11-10 |
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| Enregistrement modifié | 2020-04-22 |
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