Toward reagent-free clinical analysis: quantitation of urine urea, creatinine, and total protein from the mid-infrared spectra of dried urine films

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1093/clinchem/46.9.1493
Auteur	Rechercher : Shaw, Anthony¹; Rechercher : Low-Ying, Sarah¹; Rechercher : Leroux, Michael; Rechercher : Mantsch, Henry H.¹
Affiliation	Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
Format	Texte, Article
Résumé	Infrared (IR) spectroscopy offers an approach to clinical analysis that is conceptually very appealing. Whereas countless assays rely on the use of chemical agents to “recognize” the analyte of interest and to react with the analyte to produce specific color changes, IR-based analysis is founded on the rich IR absorption patterns that characterize the analytes themselves. These absorption patterns provide the basis to distinguish among the constituents and to separately quantify them. The most obvious distinguishing feature is that no reagents are required. In addition, IR-based analytical methods require very small sample volumes (typically microliters), show good precision over the entire physiological range, and are well suited for automation.
Date de publication	2000-09-01
Maison d’édition	Oxford University Press American Association for Clinical Chemistry
Dans	Clinical Chemistry 46, nº 9 (1 septembre 2000) : 1493–1495.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	1839
Numéro NPARC	23000794
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	9db0d4ef-00c7-4aab-844d-b400b7eeac67
Enregistrement créé	2016-10-04
Enregistrement modifié	2024-02-28

Date de modification :: 2024-04-18