DOI | Trouver le DOI : https://doi.org/10.1128/AAC.00778-12 |
---|
Auteur | Rechercher : De Léséleuc, L.1; Rechercher : Harris, G.1; Rechercher : KuoLee, R.1; Rechercher : Chen, W.1 |
---|
Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
|
---|
Format | Texte, Article |
---|
Sujet | 2,2' bipyridine; chelating agent; gallium nitrate; transferrin; Acinetobacter baumannii; animal experiment; bacterial growth; bacterial load; bacteriostasis; growth inhibition; in vitro study; in vivo study; iron metabolism; iron restriction; mouse; 2,2'-Dipyridyl; Acinetobacter baumannii; Acinetobacter Infections; Gallium; Iron Chelating Agents; Mice; Transferrin |
---|
Résumé | We investigated the ability of compounds interfering with iron metabolism to inhibit the growth of Acinetobacter baumannii. Iron restriction with transferrin or 2,2-bipyridyl significantly inhibited A. baumannii growth in vitro. Gallium nitrate alone was moderately effective at reducing A. baumannii growth but became bacteriostatic in the presence of serum or transferrin. More importantly, gallium nitrate treatment reduced lung bacterial burdens in mice. The use of gallium-based therapies shows promise for the control of multidrug-resistant A. baumannii. Copyright © 2012, American Society for Microbiology. All Rights Reserved. |
---|
Date de publication | 2012 |
---|
Dans | |
---|
Langue | anglais |
---|
Publications évaluées par des pairs | Oui |
---|
Numéro NPARC | 21269459 |
---|
Exporter la notice | Exporter en format RIS |
---|
Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
---|
Identificateur de l’enregistrement | 9977cd26-d796-4047-baf1-b7d2ea873ed0 |
---|
Enregistrement créé | 2013-12-12 |
---|
Enregistrement modifié | 2020-04-21 |
---|