Profiling brain function : Spatiotemporal characterization of normal and abnormal visual activation

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Titre de la revueJournal of Neuroscience Methods
Pages95105; nbre. de pages : 11
SujetVisual-evoked potentials (VEPs); Event-related brain potentials (ERPs); Source localization; Individual analysis; Vision impairment; Clinical assessment
RésuméObjective: In clinical neuroscience, the utility of evoked and event-related potentials (EPs and ERPs) resides in the temporal information they provide. However, it is largely unknown whether valuable diagnostic information resides within the corresponding spatial patterns. To determine this, the first step involves testing whether “normal” versus “abnormal” EPs/ERPs can be differentiated based on spatial patterns. In the current study, we present a method that characterizes similarities across individual source maps, called the profile algorithm. The profile algorithm was evaluated in terms of its ability to detect spatial activation differences in myopic individuals with corrected and uncorrected vision. This experiment represents a critical test of the method before applying it to the assessment of perceptual/cognitive functions. Methods: Visual-evoked potentials (VEPs) were recorded from healthy subjects using checkerboard stimulation. The N75 and P100 were examined in individuals with corrected (20/20) and uncorrected vision (20/40 or worse). Results and conclusion: N75 and P100 amplitudes and latencies were modulated by vision condition. The profile algorithm differentiated successfully between corrected and uncorrected vision. Its discriminatory power outperformed a more traditional method based on ERP peak amplitude. Subsequent correlations revealed significant relationships between visual impairment and both the components and the spatial activation. Overall, the findings suggested that VEP spatial patterns were sensitive to manipulations of visual acuity. Significance: The findings demonstrate that EP/ERP spatial activation can be evaluated at the individual level and compared against normative data. Ultimately, the method may provide a valuable tool for assessing individual spatial activation changes in perceptual/cognitive functions.
Date de publication
AffiliationInstitut du biodiagnostic du CNRC; Conseil national de recherches Canada
Publications évaluées par des pairsOui
Numéro NPARC17673517
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Identificateur de l’enregistrement9190f837-98fd-4b46-8039-bfd873f5dbcf
Enregistrement créé2011-04-03
Enregistrement modifié2016-05-09
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