| DOI | Trouver le DOI : https://doi.org/10.1016/j.neulet.2004.04.053 |
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| Auteur | Rechercher : Eckert, Gunter P.; Rechercher : Keller, Jan-Henning; Rechercher : Jourdan, Claudia; Rechercher : Karas, Michael; Rechercher : Volmer, Dietrich A.1; Rechercher : Schubert-Zsilavecz, Manfred; Rechercher : Muller, Walter E. |
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| Affiliation | - Conseil national de recherches du Canada. Institut des biosciences marines du CNRC
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| Format | Texte, Article |
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| Sujet | Hypericum perforatum; St. John's Wort; hyperforin; brain; membrane; fluidity; HPLC; MS |
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| Résumé | Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity. Oral administration of SJW extract and of hyperforin sodium salt results in significant hyperforin brain levels. Treatment of mice with hyperforin leads to decreased annular- and bulk fluidity and increased acyl-chain flexibility of brain membranes. All hyperforin related changes of membrane properties were significantly correlated with the corresponding hyperforin brain levels. Our data emphasises a membrane interaction of hyperforin that possibly contributes to its pharmacological effects. |
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| Date de publication | 2004-09 |
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| Conditions d’utilisation | - Copyright © 2004 Elsevier Ireland Ltd. All rights reserved.
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | 1684 |
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| Numéro NPARC | 3538168 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 82a759f8-4a3e-4b77-a26d-c0a5762ba258 |
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| Enregistrement créé | 2009-03-01 |
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| Enregistrement modifié | 2020-04-17 |
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