Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age

Par Conseil national de recherches du Canada

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DOI	Trouver le DOI : https://doi.org/10.1542/peds.2004-0997
Auteur	Rechercher : Demmers, Théa A.; Rechercher : Jones, Peter J. H.; Rechercher : Wang, Yanwen; Rechercher : Krug, Susan; Rechercher : Creutzinger, Vivian; Rechercher : Heubi, James E.
Format	Texte, Article
ISSN	0031-4005 0031-4005 0031-4005
Sujet	cholesterol; biosynthesis; infant; milk/chemistry; lipids/blood
Résumé	Background: The endogenous cholesterol fractional synthesis rate (FSR) is related inversely to infant dietary cholesterol at 4 months of age; however, it remains to be established whether this effect is permanent, possibly contributing to later hypercholesterolemia. Objective: To determine whether levels of dietary cholesterol in infancy induced changes in FSR and plasma lipid levels that persisted at 18 months. Methods. A prospective clinical trial was conducted with 47 infants, from their first week of life until 18 months of age, who received human milk (HM) until weaned (n = 15) or were randomized to receive modified cow’s milk formula (MCF) with added cholesterol (n = 15) or cow’s milk formula (CF) (n = 17) for 12 months. Cholesterol contents of HM, MCF, and CF were 120, 80, and 40 mg/L, respectively. FSR and plasma lipid levels were measured at 4 and 18 months. Results: At 4 months, total cholesterol and low-density lipoprotein cholesterol levels were higher for infants fed HM and MCF, compared with CF. High-density lipoprotein cholesterol levels were higher in the MCF group than in the HM and CF groups. FSR in the HM group (0.034 ± 0.005 pools per day) was lower than that in the CF group (0.052 ± 0.005 pools per day). There was no difference between the HM and MCF (0.047 ± 0.005 pools per day) groups or between the MCF and CF groups. At 18 months, there were no differences in FSRs or plasma lipid profiles between the groups. Conclusion: Although cholesterol intake before weaning affects FSRs and plasma lipid profiles at 4 months, these differences do not persist after weaning to an unrestricted diet at 18 months. This provides additional evidence that there is no imprinting of FSR in infancy with differing dietary levels of cholesterol. Pediatrics 2005;115:1594–1601; cholesterol, breastfed, formula-fed, fractional synthesis rate, deuterium.
Date de publication	2005-06-01
Condition d’accès	available unlimited public
Dans	Pediatrics 115, nº June 6 (1 juin 2005) : 1594–1601.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro du CNRC	NRCC 54691
Numéro NPARC	9145569
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Identificateur de l’enregistrement	7a240456-a40c-41f6-8138-a1085a88c446
Enregistrement créé	2009-10-02
Enregistrement modifié	2020-04-07

Date de modification :: 2024-04-26