| DOI | Trouver le DOI : https://doi.org/10.1039/c2jm31749d |
|---|
| Auteur | Rechercher : Zhang, X. F.1; Rechercher : Mansouri, S.; Rechercher : Clime, L.; Rechercher : Ly, H. Q.; Rechercher : Yahia, L. 'H.; Rechercher : Veres, T.1 |
|---|
| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
|
|---|
| Format | Texte, Article |
|---|
| Résumé | We demonstrate a one-step procedure for the synthesis of Fe3O4–silica core–shell nanoparticles with hierarchically ultra-large pores independent of any post-treatment such as annealing and template-molecule removal. The nanoporous silica shells with available amine groups were functionalized by clickable linkers to produce pH-sensitive amides for regulating the release of an anti-cancer drug, doxorubicin (DOX). The loading amount of DOX reached up to 13.2 mg per 100 mg nanoparticles, 74.2% of which can be effectively released after 63 h at body temperature and pH 5 with decreased side effects. Such excellent features of these nanoparticles appear to arise from the integrated hierarchically ultra-large open-porosities and a homogeneous dispersibility in aqueous solution that has a great potential for their use as drug delivery systems. |
|---|
| Date de publication | 2012-05-09 |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 21268951 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 6ec18330-3207-467e-9dac-10ec3661b4d5 |
|---|
| Enregistrement créé | 2013-11-27 |
|---|
| Enregistrement modifié | 2020-04-21 |
|---|
