| DOI | Trouver le DOI : https://doi.org/10.1016/j.carres.2013.11.006 |
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| Auteur | Rechercher : Lin, F.L.; Rechercher : Vinogradov, E.1; Rechercher : Deng, C.; Rechercher : Zeller, S.; Rechercher : Phelan, L.; Rechercher : Green, B.A.; Rechercher : Jansen, K.U.; Rechercher : Pavliak, V. |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Sujet | Capsular polysaccharides; Cross reactivity; Serogroup 33; Serotypes; Streptococcus pneumoniae; Structural assignments; Structure elucidation; Sugar residues; Acetylation; Polysaccharides; bacterial polysaccharide; epitope; galactose; glucose; monosaccharide; n acetylgalactosamine; phosphate; pneumococcal capsular polysaccharide; ribitol; ribitol phosphate; unclassified drug; acetylation; bacterial capsule; carbohydrate analysis; cross reaction; gas chromatography; heteronuclear single quantum coherence; linkage analysis; mass spectrometry; methylation; nuclear magnetic resonance spectroscopy; serotype; Streptococcus pneumoniae; Streptococcus pneumoniae |
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| Résumé | We report herein the previously unknown structures of the pneumococcal capsular polysaccharides serotype 33C and 33D, and a revised structure of serotype 33B. The syntenic pair 33B/33D has nearly identical polysaccharide repeat units with the exception of one sugar residue (→2-α-Glcp in 33B and →2-α-Galp in 33D). Serotype 33C is structurally more similar to 33B/33D than 33A/33F, in that it also possesses a backbone ribitol-phosphate group and a →3-β-GalpNAc residue, both of which are absent in the repeat units of 33A/33F. Serotype 33C is notably different from all other serogroup 33 polysaccharides, as there is no →3-β-Glcp residue and the location of the O-acetylation of the →5-β-Galf residue (O-6) differs from the other serogroup 33 polysaccharides (O-2). This completes the structural assignments of polysaccharides within serogroup 33 and provides a framework for understanding the recognition of epitopes by serogroup 33 typing sera based on observed cross-reactivities reported in the literature. © 2013 Elsevier Ltd. All rights reserved. |
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| Date de publication | 2014 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21270855 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 67056423-5d4e-4d94-8359-2c836c7a16ee |
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| Enregistrement créé | 2014-02-17 |
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| Enregistrement modifié | 2020-04-22 |
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