| Auteur | Rechercher : Jackson, Michael1; Rechercher : Mansfield, James R.1; Rechercher : Dolenko, Brion1; Rechercher : Somorjai, Rajmund L.1; Rechercher : Mantsch, Henry H.1; Rechercher : Watson, Peter H. |
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| Affiliation | - Conseil national de recherches du Canada. Institut du biodiagnostic du CNRC
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| Format | Texte, Article |
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| Sujet | breast cancer grade; classification strategy; diagnosis; estrogen receptors; Fourier transform infrared spectroscopy; multivariate analysis; progesterone receptors |
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| Résumé | Infrared (IR) spectroscopy applied to tissue sections yields complex spectra that provide a molecular fingerprint of the tissue. We have studied a cohort of 77 breast tumors by IR spectroscopy to develop an objective method for the assignment of grade of breast tumors. Although the major variations between spectra from different tumors were in absorptions arising from triglycerides (adipose tissue) and collagen, subtle changes in spectra could be detected that were independent of cellularity and tissue composition. Using a specific multivariate pattern recognition strategy to associate these changes in spectra with different tumor grades, we then were able to accurately reclassify tumors by grade (87% accuracy; κ = 0.835). A similar approach allowed classification of steroid receptor status (93% accuracy; κ = 0.852). We conclude that IR spectroscopy may have clinical utility in the objective assignment of breast tumor grade. |
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| Date de publication | 1999-05 |
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| Maison d’édition | International Society for Preventive Oncology (ISPO) |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | NRC-IBD-876 |
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| Numéro NPARC | 9147863 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 59f1d772-8963-49c4-acad-f0867ec08bcb |
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| Enregistrement créé | 2009-06-25 |
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| Enregistrement modifié | 2020-03-20 |
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