Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1078/0944-7113-00004
Auteur	Rechercher : Banskota, A. H.; Rechercher : Tezuka, Y.; Rechercher : Adnyana, I. K.; Rechercher : Ishii, E.; Rechercher : Midorikawa, K.; Rechercher : Matsushige, K.; Rechercher : Kadota, S.
Format	Texte, Article
Sujet	Brazilian propolis; hepatoprotective activity; Helicobacter pylori; DPPH free radical scavenging activity; prenylated phenolic compound; labdane-type diterpene
Résumé	Propolis is a resinous hive product collected by honeybees from various plant sources. It is extensively used in food, beverage and in folk medicine for treating various ailments and reported to have broad spectrum of biological activities. The hepatoprotective activity of propolis and constituents from its MeOH extract belonging to various classes were tested on D-galactosamine (d-GalN)/tumor necrosis factor-α (TNF-α)-induced cell death in primary cultured mouse hepatocytes. The result indicated that hepatoprotective activity of alcoholic extract of tropical Brazilian propolis is mainly due to phenolic compounds including flavonoids. All the four isolated flavonoids possessed stronger inhibitory activity (IC50, less than 25 μM) than silibinin (IC50, 39.6 μM) on TNF-α-induced cell death. The labdane-type diterpenes isolated from the MeOH extract also exhibited significant hepatoprotective activity in the same experimental model. Moreover, the labdane-type diterpenes and some of the prenylated phenolic compounds possessed antibacterial activity against Helicobacter pylori.
Date de publication	2001-01-31
Dans	Phytomedicine 8, nº 1 (31 janvier 2001) : 16–23.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	21274816
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	47c51756-e15e-418b-b1b3-ba168026eedc
Enregistrement créé	2015-04-14
Enregistrement modifié	2020-03-27

Date de modification :: 2024-04-20