| DOI | Trouver le DOI : https://doi.org/10.1016/j.brainres.2010.10.008 |
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| Auteur | Rechercher : Whitehead, Shawn N.1; Rechercher : Massoni, Erika; Rechercher : Cheng, Guanliang1; Rechercher : Hachinski, Vladimir C.; Rechercher : Cimino, Mauro; Rechercher : Balduini, Walter; Rechercher : Cechetto, David F. |
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| Affiliation | - Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
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| Format | Texte, Article |
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| Résumé | Clinical data has shown that stroke exacerbates dementia in Alzheimer's disease (AD) patients. Previous work, combining ratmodels ofADand stroke have shown that neuroinflammationmay be the common mediator between AD and stroke toxicity. This study examined the effects of triflusal (2-acetoxy-4-trifluoromethylbenzoic acid) in APP23 transgenicmice receiving strokes. Six month-old APP23 mice over-expressing mutant human amyloid precursor protein (APP) were used to model AD in this study. Unilateral injections of a potent vasoconstrictor, endothelin-1, into the striatumwere used tomimic small lacunar infarcts. Immunohistochemical analysis was performed to examine AD-like pathology and inflammatory correlates of stroke and AD. APP23 mice showed increases in AD-like pathology and inflammatorymarkers of AD in the cortex and hippocampus. Endothelin-induced ischemia triggered an inflammatory response along with increases in AD pathologicalmarkers in the region of the infarct. Triflusal reduced inflammation surrounding the endothelin-induced infarct only.At thedoseused,anti-inflammatory treatment may be beneficial in reducing the AD and inflammatory correlates of stroke in a combined ADstroke mouse model. |
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| Date de publication | 2010-12-17 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 17652984 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 2b90de1c-9721-4a6a-a161-79c88ff5c095 |
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| Enregistrement créé | 2011-04-01 |
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| Enregistrement modifié | 2020-04-17 |
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