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Transcriptional analysis of the Candida albicans cell cycle

Par Conseil national de recherches du Canada

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DOITrouver le DOI : https://doi.org/10.1091/mbc.E09-03-0210
AuteurRechercher : 1; Rechercher : 1; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Institut de recherche en biotechnologie du CNRC
FormatTexte, Article
SujetBiotechnology; Candida; Candida albicans; Cell Cycle; Cells; cytology; DNA Replication; Gene Expression Profiling; Gene Expression Regulation,Fungal; Genes; Genes,Fungal; genetics; metabolism; pharmaceutical; Protein; Protein Subunits; Saccharomyces cerevisiae; Time Factors; Transcription Factors; Transcription,Genetic; Yeast; Yeasts
Résumé
We have examined the periodic expression of genes through the cell cycle in cultures of the human pathogenic fungus Candida albicans synchronized by mating pheromone treatment. Close to 500 genes show increased expression during the G1, S, G2, orMtransitions of the C. albicans cell cycle. Comparisons of these C. albicans periodic genes with those already found in the budding and fission yeasts and in human cells reveal that of 2200 groups of homologous genes, close to 600 show periodicity in at least one organism, but only 11 are periodic in all four species. Overall, the C. albicans regulatory circuit most closely resembles that of Saccharomyces cerevisiae but contains a simplified structure. Although the majority of the C. albicans periodically regulated genes have homologues in the budding yeast, 20% (100 genes), most of which peak during the G1/S or M/G1 transitions, are unique to the pathogenic yeast.
Date de publication
Dans
  • Molecular Biology of the Cell 20, nº 14 (28 mai 2009) : 3363–3373.
Langueanglais
Numéro du CNRCNRCC 50665
Numéro NPARC12907046
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Identificateur de l’enregistrement19d1424a-219a-49f6-aa38-f3e17540f475
Enregistrement créé2009-11-10
Enregistrement modifié2020-04-16
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