Hepatoprotective constituents of the seeds of Combretum quadrangulare

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1248/bpb.23.1328
Auteur	Rechercher : Adnyana, I Ketut; Rechercher : Tezuka, Yasuhiro; Rechercher : Banskota, Arjun Hari; Rechercher : Tran, Kim Qui; Rechercher : Kadota, Shigetoshi
Format	Texte, Article
Sujet	Combretum quadrangulare; Vietnamese medicinal plant; hepatoprotective effect; triterpene glucoside; catechin; 1-O-galloyl-6-O-(4-hidroxy-3, 5-dimethoxy)benzoyl-β-D-glucose
Résumé	Hepatoprotective effect of MeOH, MeOH-H2O (1 : 1) and H2O extracts of Combretum quadrangulare seeds were examined on D-galactosamine (D-GalN)/tumor necrosis factor-α(TNF-α)-induced cell death in primary cultured mouse hepatocytes. The MeOH extract showed the strongest inhibitory effect on D-GalN/TNF-α-induced cell death (IC50, 56.4μg/ml). Moreover, the MeOH extract also significantly lowered the serum glutamic pyruvic transaminase (sGPT) level on D-GalN/lipopolysaccharide (LPS)-induced liver injury in mice. Bioguided separation of the MeOH extract led to the isolation of 38 compounds of various classes including triterpene glucosides, lignans and catechin derivatives. Among the isolated triterpene glucosides, lupane-type (1-3; IC50, 63.1, 59.8 and 76.2μM, respectively) and ursane-type (11, mixture of 12 and 14; IC50, 30.2 and 34.6μM, respectively) compounds exhibited strong hepatoprotective activity. 1-O-Galloyl-6-O-(4-hydroxy-3, 5-dimethoxy)benzoyl-β-D-glucose (26; IC50, 7.2μM), methyl gallate (28; IC50, 19.9μM), and (-)-epicatechin (31; IC50, 71.2μM) also had a potent hepatoprotective effect on D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes.
Date de publication	2000-11-01
Dans	Biological and Pharmaceutical Bulletin 23, nº 11 (1 novembre 2000) : 1328–1332.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	21275300
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Identificateur de l’enregistrement	15dd152f-1e28-4460-9c17-94ff39dcb5c6
Enregistrement créé	2015-06-04
Enregistrement modifié	2020-03-26

Date de modification :: 2024-04-26