| Téléchargement | - Voir le manuscrit accepté : Low-Temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications (PDF, 2.1 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1021/am302951k |
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| Auteur | Rechercher : Yu, Kui1; Rechercher : Ng, Peter2; Rechercher : Ouyang, Jianying1; Rechercher : Zaman, Md. Badruz3; Rechercher : Abulrob, Abedelnasser4; Rechercher : Baral, Toya Nath4; Rechercher : Fatehi, Dorothy4; Rechercher : Jakubek, Zygmunt J.5; Rechercher : Kingston, David6; Rechercher : Wu, Xiaohua7; Rechercher : Liu, Xiangyang1; Rechercher : Hebert, Charlie2; Rechercher : Leek, Donald M.5; Rechercher : Whitfield, Dennis M.4 |
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| Affiliation | - Conseil national de recherches du Canada. Technologies de sécurité et de rupture
- Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
- Conseil national de recherches du Canada
- Conseil national de recherches du Canada. Thérapeutique en santé humaine
- Conseil national de recherches du Canada. Science des mesures et étalons
- Conseil national de recherches du Canada. Énergie, les mines et l'environnement
- Conseil national de recherches du Canada. Technologies de l'information et des communications
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| Format | Texte, Article |
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| Sujet | CuInS2 nanocrystals; quantum dots; diphenylphosphine sulphide; in vitro imaging; in vivo imaging |
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| Résumé | We report our newly developed low-temperature synthesis of colloidal photoluminescent (PL) CuInS2 nanocrystals (NCs) and their in vitro and in vivo imaging applications. With diphenylphosphine sulphide (SDPP) as a S precursor made from elemental S and diphenylphosphine, this is a noninjection based approach in 1-dodecanethiol (DDT) with excellent synthetic reproducibility and large-scale capability. For a typical synthesis with copper iodide (CuI) as a Cu source and indium acetate (In(OAc)3) as an In source, the growth temperature was as low as 160 C and the feed molar ratios were 1Cu-to-1In-to-4S. Amazingly, the resulting CuInS2 NCs in toluene exhibit quantum yield (QY) of ∼23% with photoemission peaking at ∼760 nm and full width at half maximum (FWHM) of ∼140 nm. With a mean size of ∼3.4 nm (measured from the vertices to the bases of the pyramids), they are pyramidal in shape with a crystal structure of tetragonal chalcopyrite. In situ 31P NMR (monitored from 30 C to 100 C) and in situ absorption at 80 C suggested that the Cu precursor should be less reactive toward SDPP than the In precursor. For our in vitro and in vivo imaging applications, CuInS 2/ZnS core-shell QDs were synthesized; afterwards, dihydrolipoic acid (DHLA) or 11-mercaptoundecanoic acid (MUA) were used for ligand exchange and then bio-conjugation was performed. Two single-domain antibodies (sdAbs) were used. One was 2A3 for in vitro imaging of BxPC3 pancreatic cancer cells. The other was EG2 for in vivo imaging of a Glioblastoma U87MG brain tumour model. The bioimaging data illustrate that the CuInS2 NCs from our SDPP-based low-temperature noninjection approach are good quality. |
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| Date de publication | 2013-03-13 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro du CNRC | NRC-HHT-53277 |
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| Numéro NPARC | 21270647 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 10633ab5-bcb2-48c1-95b0-7e32cbd1efd6 |
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| Enregistrement créé | 2014-02-17 |
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| Enregistrement modifié | 2020-06-04 |
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