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Vaccines against Francisella tularensis

Par Conseil national de recherches du Canada

DOITrouver le DOI : https://doi.org/10.1196/annals.1409.012
AuteurRechercher : 1; Rechercher :
Affiliation
  1. Conseil national de recherches du Canada. Institut des sciences biologiques du CNRC
FormatTexte, Article
Sujetadverse effects; bacterial vaccines; Francisella tularensis; genetics; immunity, cellular; immunity, natural; immunology; molecular; mutation; pathogenicity; physiology; potential; prevention & control; strain; tularemia; united states food and drug administration; vaccines; virulence; virulence factors
Résumé
Francisella tularensis is one of the most pathogenic pathogens known, especially when disseminated as a small particle aerosol. Because of this, it was developed into a biological warfare agent by several states during the 20th century. Nowadays, concerns remain about the potential of this pathogen to cause widespread disease, tularemia, in the hands of terrorists. This has resurrected interest in methods to combat it. This article reviews the current status of vaccine development efforts against tularemia. To date most of our understanding of tularemia vaccine efficacy has been derived from the clinical and experimental use of a pragmatically attenuated live vaccine strain of F. tularensis subspecies holarctica. However, this vaccine which has been in existence for more than 50 years is still beset by regulatory issues that continue to hamper its licensure. These issues and possible solutions are highlighted, along with more modern molecular approaches to vaccine development against this highly virulent pathogen.
Date de publication
Maison d’éditionWiley
Dans
  • Annals of the New York Academy of Sciences 1105, nº 1 : 325–350.
Langueanglais
Publications évaluées par des pairsOui
Numéro du CNRCCONLAN2007
WAYNE2007
Numéro NPARC9368974
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Identificateur de l’enregistrement0171d21c-5aba-49ef-a00b-64ae55af6698
Enregistrement créé2009-07-10
Enregistrement modifié2020-05-10
Date de modification :