Microbial genome sequencing and pathogenesis: Curr.Opin.Microbiol

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Journal titleCurr.Opin.Microbiol
Pages1216; # of pages: 5
SubjectAntigenic Variation; Escherichia coli; ESCHERICHIA-COLI; Genome,Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Helicobacter pylori; Human; Open Reading Frames; Sequence Analysis,DNA; Virulence
AbstractThe year 1997 saw the publication of the complete nucleotide sequence of Helicobacter pylori and Escherichia coli. It is conceivable that the complete nucleotide sequence for all the major human bacterial pathogens will be available by the end of the century. Database alignments have been used to ascribe the putative functions of open reading frames in the sequenced isolates and to define the differences between bacterial species at the nucleotide level. The most striking finding from all genome projects has been the high proportion of open reading frames that have no known function. Experimental data demonstrating the utility of the genome sequencing projects are only just beginning to emerge Type: JOURNAL ARTICLE Type: REVIEW Type: REVIEW, TUTORIAL Language: Eng
Publication date
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberTANG1998
NPARC number9379963
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Record identifierff28b0ff-8bc0-4a27-8e93-a11d6aa980de
Record created2009-07-10
Record modified2016-05-09
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