Benzofuran-Derived Cyclic β-Amino Acid Scaffold for Building a Diverse Set of Flavonoid-Like Probes and the Discovery of a Cell Motility Inhibitor

DOI	Resolve DOI: https://doi.org/10.1021/ol800050g
Author	Search for: Nandy, Jyoti¹; Search for: Rakic, B.; Search for: Sarma, B.; Search for: Babu, N.; Search for: Lefrance, M.; Search for: Enright, Gary¹; Search for: Leek, Donald¹; Search for: Daniel, K.; Search for: Sabourin, L.; Search for: Arya, Prabhat¹
Affiliation	National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
Format	Text, Article
Abstract	We report here a practical, enantioselective synthesis of benzofuran-derived, cyclic trans--amino acid scaffold. In two cases, tricyclic derivatives having six- and eight-membered unsaturated lactams were obtained from this versatile scaffold. To explore the biological applications, these compounds were subjected to cell-based assays, using NIH3T3 mouse cells to examine their potency as cell motility inhibitors and identified 18 as a potent cell motility inhibitor (IC50 40 M in chamber cell migration assay).
Publication date	2008-03-20
In	Organic Letters 10, no. 6 (20 March 2008): 1143–1146.
NPARC number	12328244
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Record identifier	fe29207a-427b-49dd-8f27-4d76e6b137dd
Record created	2009-09-10
Record modified	2020-04-15