Language selection

Government of Canada / Gouvernement du Canada

Search

Constitutive Modelling of Endothelium Denudation for Finite Element Simulation of Angioplasty

From National Research Council Canada

Download
  1. (PDF, 2.0 MiB)
DOIResolve DOI: https://doi.org/10.1007/978-3-540-70521-5_3
AuthorSearch for: 1; Search for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Industrial Materials Institute
FormatText, Article
ConferenceInternational Symposium on Computational Models for Biomedical Simulation - ISBMS08, London, UK, July 7-8, 2008
Subjectangioplasty; restenosis; endothelium; stretch; friction; pressure
Abstract
This study aims at characterizing and modelling the effect of mechanical factors on endothelial denudation during angioplasty, such as normal force between balloon and artery, stretching of arterial walls, and relative displacement between contacting surfaces. Friction damage was applied to porcine aorta samples with different contact forces, relative displacements, and biplanar stretching conditions. After the tests, endothelium denudation was quantified by isolating and counting the remaining endothelial cells. Using multiple-regression analysis, a constitutive model is proposed for integration in finite element software. This model will help optimize balloon and stent deployment conditions to minimize the amount of damage to the endothelium, and eventually to reduce the occurrence of restenosis.
Publication date
In
  • Biomedical Simulation. 4th International Symposium, ISBMS 2008, London, UK, July 7-8, 2008. Proceedings (2008): 19–27.
  • Lecture notes in Computer Science 5104.
LanguageEnglish
Peer reviewedYes
NRC numberNRCC 50250
NRCC 52324
NPARC number18890171
Export citationExport as RIS
Report a correctionReport a correction (opens in a new tab)
Record identifierf00fb9f1-6698-4454-942d-5fd81dd312f9
Record created2011-11-04
Record modified2020-04-15
Date modified: