| Download | - View accepted manuscript: Solution- and solid-phase synthesis of tetrahydroquinoline-based polycyclics having α,β -unsaturated γ-lactam and δ-lactone functionalities (PDF, 565 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1055/s-0029-1218576 |
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| Author | Search for: Khadem, Shahriar1; Search for: Udachin, Konstantin A.1; Search for: Arya, Prabhat1 |
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| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Subject | lactams; lactones; fused-ring systems; heterocycles; asymmetric synthesis; solid-phase synthesis |
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| Abstract | With the goal of the library generation using the tetrahydroquinoline- based derivative, a simple and practical enantioselective synthesis of the tetrahydroquinoline derivatives having a,bunsaturated g-lactam and d-lactone functional groups was achieved. The phenolic hydroxy group in the a,b-unsaturated g-lactam was utilized as an anchoring site for the solid-phase synthesis. The ringclosing metathesis approach yielded the desired tricyclic products on the solid phase. |
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| Publication date | 2010 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17673537 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | ec9e57f4-c689-4ab9-a6eb-91e1458bc1ff |
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| Record created | 2011-04-03 |
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| Record modified | 2020-04-17 |
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