| Download | - View accepted manuscript: Low thrombogenicity coating of nonwoven PET fiber structures for vascular grafts (PDF, 1.0 MiB)
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| DOI | Resolve DOI: https://doi.org/10.1002/mabi.201000390 |
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| Author | Search for: Dimitrievska, Sashka1; Search for: Maire, Marion1; Search for: Diaz-Quijada, Gerardo A.1; Search for: Robitaille, Lucie1; Search for: Ajji, Abdellah; Search for: Yahia, L’Hocine; Search for: Moreno, Maria2; Search for: Merhi, Yahye; Search for: Bureau, Martin N.1 |
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| Affiliation | - National Research Council of Canada. NRC Industrial Materials Institute
- National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Abstract | Vascular PET grafts (Dacron) have shown good performance in large vessels (≥6mm) applications. To address the urgent unmet need for small-diameter (2–6mm) vascular grafts, proprietary high-compliance nonwoven PET fiber structures were modified with various PEG concentrations using PVA as a cross-linking agent, to fabricate non-thrombogenicmechanically compliant vascular grafts. The blood compatibility assays measured through platelet adhesion (SEM and mepacrine dye) and platelet activation (morphological changes, P-selectin secretion, and TXB2 production) demonstrate that functionalization using a 10% PEG solution was sufficient to significantly reduce platelet adhesion/activation close to optimal literature-reported levels observed on carbon-coated ePTFE. |
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| Publication date | 2011-01-21 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRCC 53825 |
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| NPARC number | 18370421 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | e1c5bdba-06ee-4e99-9f88-82cbea296866 |
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| Record created | 2011-08-03 |
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| Record modified | 2020-04-21 |
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