Oxidative transformation of a naturally occurring okadaic acid diol ester by the diatom Thalassiosira weissflogii

DOI	Resolve DOI: https://doi.org/10.1016/S0040-4039(99)00516-X
Author	Search for: Hu, Tingmo¹; Search for: Burton, Ian¹; Search for: Curtis, Jonathan M.¹; Search for: Quilliam, Michael A.¹; Search for: Walter, John A.¹; Search for: Windust, Anthony J.; Search for: Wright, Jeffrey L.C.¹
Affiliation	National Research Council of Canada. NRC Institute for Marine Biosciences
Format	Text, Article
Subject	diarrhetic shellfish poison; DSP; okadaic acid; dinoflagellate; Prorocentrum lima; diatom; Thalassiosira weissflogii
Abstract	The diarrhetic shellfish poisoning (DSP) toxin okadaic acid (1) is found in extracts of the dinoflagellate Prorocentrum lima together with a suite of diol esters such as 2. When 2 was added to the culture medium of the centric diatom Thalassiosira weissflogii, it was transformed into a range of products within three days. Three of these products, 3, 4 and 5, were isolated from the medium and identified as oxidation products 2, suggesting that the diatom produces DSP metabolites of greater polarity as a means of detoxification. In addition, another diol ester product 6 was identified as a minor impurity of 2.
Publication date	1999-05
In	Tetrahedron Letters 40, no. 21: 3981–3984.
Language	English
Peer reviewed	Yes
Identifier	S004040399900516X
NPARC number	23001072
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Record identifier	d1c1d463-1c30-4b95-a8f1-d63a90bb4950
Record created	2016-12-08
Record modified	2020-03-20