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Conformation of the peptide hormone somatostatin in aqueous solution and organic solvents

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/0924-2031(92)85010-X
AuthorSearch for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Institute for Biodiagnostics
FormatText, Article
SubjectInfrared spectrometry; Conformational analysis; Peptide hormones; Somatostatin
Abstract
Fourier transform infrared spectroscopy was applied to the conformational analysis of somatostatin in H₂O, ²H₂O, dimethyl sulphoxide (DMSO)-²H₂O and DMSO. The results suggest that in these solvents the peptide adopts a similar structure. In agreement with circular dichroism (CD) spectroscopic data, evidence for turn structures was found; however, there was no evidence for the intramolecular β-sheet secondary structures proposed on the basis of Raman and CD spectroscopic results. Rather, the amide C=O and NH groups not involved in turns appear to be either hydrogen bonded to the solvent or free.
Publication date
In
  • Vibrational Spectroscopy 3, no. 4: 323–326.
LanguageEnglish
Peer reviewedYes
NRC numberNRC-IBD-45
NPARC number9741988
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Record identifiercf507813-bb51-481c-bac1-c3ac904061b4
Record created2009-07-17
Record modified2020-04-24
Date modified: