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Organic reducing agents. Reduction of electron deficient bromides by 1,2,2,6,6-pentamethylpiperidine (PMP)/mercaptoethanol

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/0040-4039(95)00697-B
AuthorSearch for: 1; Search for: 1; Search for: 1
Affiliation
  1. National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
FormatText, Article
Abstract
1,2,2,6,6-pentamethylpiperidine (PMP) is shown to be an effective reducing agent for the radical chain conversion of primary bromoesters to the corresponding esters. The problem of inefficient reduction of tertiary bromoesters in these reactions has been overcome by the addition of an alkyl thiol which mediates the hydrogen atom transfer between the two hindered alkyl centers.
Publication date
In
  • Tetrahedron Letters 36, no. 23 (5 June 1995): 3997–4000.
LanguageEnglish
NPARC number12333661
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Record identifiercde0b12a-b648-4407-b3a0-1c85d559ff81
Record created2009-09-10
Record modified2020-04-29
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