Download | - View accepted manuscript: Studies of the biosynthesis of DTX-5a and DTX-5b by the Dinoflagellate Prorocentrum maculosum : regiospecificity of the putative Baeyer−Villigerase and insertion of a single Amino Acid in a Polyketide chain (PDF, 662 KiB)
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DOI | Resolve DOI: https://doi.org/10.1021/jo0204754 |
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Author | Search for: Macpherson, Gordon R.1; Search for: Burton, Ian W.1; Search for: Leblanc, Patricia1; Search for: Walter, John A.1; Search for: Wright, Jeffrey L. C.1 |
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Affiliation | - National Research Council of Canada. NRC Institute for Marine Biosciences
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Format | Text, Article |
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Subject | amino acid; dinophysistoxin 1; dinophysistoxin 5a; dinophysistoxin 5b; glycine; oxygen; polyketide; unclassified drug |
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Abstract | The biosynthetic origins of the diarrhetic shellfish poisoning toxins DTX-5a and DTX-5b have been elucidated by supplementing cultures of the producing organism Prorocentrum maculosum with stable isotope labeled precursors and determining the incorporation patterns by 13C NMR spectroscopy. The amino acid residue in the sulfated side chain is found to originate from glycine, and oxygen insertion in the chain is shown to occur after polyketide formation. |
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Publication date | 2002-12-19 |
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In | |
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Language | English |
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Peer reviewed | Yes |
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NRC number | NRCC 42372 |
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NPARC number | 21271014 |
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Export citation | Export as RIS |
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Report a correction | Report a correction (opens in a new tab) |
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Record identifier | c08a8464-3bd6-42b5-ab4b-84bd729f6dee |
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Record created | 2014-03-12 |
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Record modified | 2020-06-04 |
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