Drosophila innate immunity and response to fungal infections

DOIResolve DOI: http://doi.org/10.1111/j.1462-5822.2008.01120.x
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SubjectAdult; analysis; Cell Line; Drosophila; Drosophila melanogaster; genetics; pha
AbstractThe fruit fly Drosophila melanogaster is an important model for the analysis of the interaction between host immune systems and fungal pathogens. Recent experiments have extended our understanding of the Toll-based signalling pathway critical to response to fungal infections, and identified new elements involved in cellular and humoral-based defences. The fly immune system shows remarkable sophistication in its ability to discriminate among pathogens, and the powerful genetics available to researchers studying the adult fly response, and the ability to manipulate cultured phagocytic cell lines with RNAi, are allowing researchers to dissect the molecular details of the process
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AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number49547
NPARC number3538893
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Record identifierbe1ff259-05dd-44d2-96d4-b9ee9aca97c4
Record created2009-03-01
Record modified2016-05-09
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