| DOI | Resolve DOI: https://doi.org/10.3233/JAD-2012-120115 |
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| Author | Search for: Chakravarthy, B.1; Search for: Ménard, M.1; Search for: Ito, S.1; Search for: Gaudet, C.1; Search for: Dal Prà, I.; Search for: Armato, U.; Search for: Whitfield, J.1 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Biological Sciences
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| Format | Text, Article |
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| Subject | amyloid beta protein[1-42]; neurotrophin receptor p75; adult; aged; Alzheimer disease; autopsy; brain tissue; clinical article; cognition; female; frontal cortex; hippocampus; human cell; human cell culture; human tissue; male; mouse; neuroblastoma cell; aged, 80 and over; Alzheimer disease; cell line, tumor; cell membrane; female; frontal lobe; hippocampus; male; middle aged; neurons; receptor, nerve growth factor; tumor cells, cultured |
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| Abstract | The pan-specific p75 neurotrophin receptor (p75 NTR) is believed to play an important role in the pathogenesis of Alzheimer's disease (AD). It is involved in mediating amyloid-β (Aβ) toxicity and stimulating amyloidogenesis. In addition, we have recently shown that stimulating cultured SH-SY5Y human neuroblastoma cells with Aβ 42 increases the level of membrane-associated p75 NTR and that Aβ 42- accumation in two strains of transgenic AD model mice is accompanied by an increased level of hippocampal membrane-associated p75 NTR (Chakravarthy et al. J Alzheimers Dis 19, 915-925, 2010). This raised an important question whether accumulating Aβ 42 in human AD is also accompanied by an increased hippocampal membrane-associated p75 NTR. In this study, using polyclonal and monoclonal antibodies against the p75 NTR receptor's intra-and extracellular domains, we show that indeed the mean level of membrane-associated p75 NTR in the hippocampal formation is significantly higher (~two-fold, p < 0.03) in human AD brains than in identical samples of hippocampal formation in age-matched non-AD human brains. The possible relation of this elevated hippocampal p75 NTR to AD cognitive decline is discussed. © 2012 -IOS Press and the authors. |
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| Publication date | 2012 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21269238 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | bcf39eff-1592-4ba5-8e39-bc6d3a11d6ca |
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| Record created | 2013-12-12 |
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| Record modified | 2020-04-21 |
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