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Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np020235j
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FormatText, Article
Abstract
Three new C-14 oxygenated taxane-type diterpenes, hongdoushans A−C (1−3), were isolated from the wood of Taxus yunnanensis together with four known diterpenes and two lignans. The absolute stereochemistry of the 2-methylbutyryloxy group attached at C-14 of the taxane skeleton was determined to be S by GC analysis of the methyl ester of 2-methylbutyric acid obtained after alkaline hydrolysis of 1 and 4 followed by treatment with CH2N2. The complete stereostructure of the known compound 2α,5α,10β-triacetoxy-14β-[(S)-2-methylbutyryloxy]-4(20),11-taxadiene (4) was established for the first time. The isolates obtained were evaluated for their antiproliferative activity toward murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.
Publication date
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  • Journal of Natural Products 65, no. 11 (12 September 2002): 1700–1702.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274774
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Record identifierbbaa7141-f434-49e2-8a93-984300acd246
Record created2015-04-08
Record modified2020-03-30
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