CMP-Pseudaminic acid is a natural potent inhibitor of PseB, the first enzyme of the pseudaminic acid pathway in Campylobacter jejuni and Helicobacter pylori

DOI	Resolve DOI: https://doi.org/10.1002/cmdc.200700170
Author	Search for: McNally, David J.¹; Search for: Schoenhofen, Ian C.¹; Search for: Houliston, R. Scott¹; Search for: Khieu, Nam¹; Search for: Whitfield, Dennis M.¹; Search for: Logan, Susan M.¹; Search for: Jarrell, Harold C.¹; Search for: Brisson, Jean-Robert¹
Affiliation	National Research Council of Canada. NRC Institute for Biological Sciences
Format	Text, Article
Subject	ACID; Campylobacter; Campylobacter jejuni; ENZYME; Helicobacter pylori; INHIBITOR; PATHWAY; POTENT
Abstract	Deadly decorations. Campylobacter jejuni and Helicobacter pylori decorate their flagella, which are essential for virulence, with pseudaminic acid (Pse). Pse production is feedback-regulated in the bacterial cell by CMP-pseudaminic acid, a potent inhibitor of PseB, the first enzyme of the Pse pathway. Herein, STD NMR was used to map binding epitopes for PseB and to characterize the interaction between PseB and CMP-Pse.
Publication date	2007-09-24
Publisher	Wiley
In	ChemMedChem 3, no. 1.
Language	English
Peer reviewed	Yes
NRC number	MCNALLY2008
NPARC number	9376904
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Record identifier	ba0f0a00-26d0-48ea-a4f9-8f6b3527c0be
Record created	2009-07-10
Record modified	2020-05-10