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Benzodiazepine receptor involvement in the control of receptive field size and responsiveness in primary somatosensory cortex

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/0006-8993(86)90917-0
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FormatText, Article
SubjectS1 cortex; receptive field; benzodiazepine; Ro 15-1788; flurazepam; diazepam; midazoalm
Abstract
Microiontophoretic ejection of 3 benzodiazepines (BZDs), flurazepam, diazepam and midazolam, and of Ro 15-1788 to primary somatosensory cortical neurons altered the nature of the responses evoked by natural stimulation of the cutaneous surface. BZDs raised the thresholds to tactile stimulation and produced a decrease of the receptive field areas of neurons situated in rapidly adapting submodality regions of S1 cortex; these effects of the BZDs were exerted at different apparent potencies. Ro 15-1788 antagonized the BZDinduced receptive field size decreases and threshold changes. When administered alone, this substance sometimes lowered the threshold for tactile activation and slightly enlarged the receptive field size.
Publication date
In
  • Brain Res. 376, no. 1 (18 June 1986): 194–198.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NRC numberOKA1986
NPARC number9380446
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Record identifierb71253ee-c28f-4d02-81ec-65ac87a8b518
Record created2009-07-10
Record modified2020-03-17
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