The need to revisit lipid areas

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Proceedings titleJournal Of Physics
ConferenceInternational Conference on Neutron Scattering 2009, May 3-7, 2009, Knoxville, Tennessee
Pages14; # of pages: 4
AbstractWe have studied the structural properties of lipid bilayers made up of monounsaturated phosphatidylcholines (i.e. diCn:1PC, where n=14, 16, 18, 20, 22 and 24). High-resolution x-ray scattering data were analyzed in conjunction with contrast varied neutron scattering data, using the recently developed technique by Ku_erka et al. [Biophys. J. 95, 2356 (2008)]. Analyses of the data show that with increasing n lipid bilayers do not thicken in a linear fashion, as is often assumed, but quadratically, and that lipid area assumes a maximum value for n~18 bilayers. More importantly, compared to previous data our results strongly suggest that lipid areas are smaller by about 10%. This observation highlights the need to revisit lipid areas as they are extensively used in molecular dynamics simulations and for calibrating their force fields.
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AffiliationNRC Canadian Neutron Beam Centre; National Research Council Canada
Peer reviewedYes
NPARC number16945673
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Record identifiera8fe39fa-2818-4ce7-98bb-0a97baaae465
Record created2011-03-03
Record modified2016-05-09
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