| DOI | Resolve DOI: https://doi.org/10.1039/c1cc13808a |
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| Author | Search for: McKay, C.S.1; Search for: Blake, J.A.1; Search for: Cheng, J.1; Search for: Danielson, D.C.1; Search for: Pezacki, J.P.1 |
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| Affiliation | - National Research Council of Canada. NRC Steacie Institute for Molecular Sciences
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| Format | Text, Article |
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| Subject | alkyne; azide; cyclic nitrone; cyclooctyne; nitrone; unclassified drug; cancer cell; chemical labeling; chemical reaction; chemical structure; cycloaddition; liver cell; Alkynes; Azides; Catalysis; Cell Line, Tumor; Cyclization; Kinetics; Neoplasms; Nitrogen Oxides; Receptor, Epidermal Growth Factor |
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| Abstract | Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M -1 s -1 in CD 3CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells. © The Royal Society of Chemistry 2011. |
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| Publication date | 2011 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21271593 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | a387fa27-ed1e-4f40-b37c-2c41f01a3871 |
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| Record created | 2014-03-24 |
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| Record modified | 2020-04-21 |
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