Antibody recognition of carbohydrate epitopes

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Journal titleGlycobiology
Pages920952; # of pages: 33
SubjectAnti-carbohydrate antibodies; carbohydrate recognition; Chlamydia; HIV-1 gp120; lipopolysaccharide; monoclonal antibody; X-ray crystal structures
AbstractCarbohydrate antigens are valuable as components of vaccines for bacterial infectious agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics against cancer. The crystal structures of anti-carbohydrate antibodies in complex with antigen reveal the key features of antigen recognition and provide information that can guide the design of vaccines, particularly synthetic ones. This review summarizes structural features of anti-carbohydrate antibodies to over 20 antigens, based on six categories of glyco-antigen: (i) the glycan shield of HIV glycoproteins; (ii) tumor epitopes; (iii) glycolipids and blood group A antigen; (iv) internal epitopes of bacterial lipopolysaccharides; (v) terminal epitopes on polysaccharides and oligosaccharides, including a group of antibodies to Kdo-containing Chlamydia epitopes; and (vi) linear homopolysaccharides.
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AffiliationNational Research Council Canada (NRC-CNRC); Human Health Therapeutics
Peer reviewedYes
NPARC number21277037
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Record identifier9f334212-7476-4082-a512-7812740f9d70
Record created2015-11-10
Record modified2016-05-09
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