DOI | Resolve DOI: https://doi.org/10.1039/c3tb21362e |
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Author | Search for: Liu, Shuhan; Search for: Ko, Alex C.-T.1; Search for: Li, Wenyan; Search for: Zhong, Wen; Search for: Xing, Malcolm |
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Affiliation | - National Research Council of Canada. Medical Devices
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Format | Text, Article |
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Abstract | In this work, we synthesized a pH sensitive poly(ethylene glycol)-doxorubicin (PEG-DOX) on single-wall carbon nanotubes (SWNTs). Using multimodal nonlinear optical imaging microscopy, we found that low power (1 mW cm-2) near-infrared radiation can initiate prodrug burst release from the carbon nanotubes in seconds. The successful SWNTs capping with PEG-DOX (denoted PEG-DOX@SWNT) was determined by transmission electron microscopy and FTIR results. The in vitro release of DOX from the PEG-DOX@SWNT was evaluated upon changes of pH values and NIR treating time. The cytotoxicity of the PEG-DOX@SWNT was also evaluated. This dual-sensitive delivery system based on SWNTs provides a facile approach to promote drug release and kill cancer cells. |
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Publication date | 2014-03 |
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In | |
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Language | English |
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Peer reviewed | Yes |
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NPARC number | 21272775 |
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Export citation | Export as RIS |
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Report a correction | Report a correction (opens in a new tab) |
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Record identifier | 95298f71-c9da-47df-8dd0-a46861557c1b |
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Record created | 2014-12-03 |
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Record modified | 2020-04-22 |
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