| Download | - View accepted manuscript: Performance analysis of a swept-source optical coherence tomography system with a quadrature interferometer and optical amplification (PDF, 880 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1016/j.optcom.2011.01.016 |
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| Author | Search for: Mao, Youxin1; Search for: Flueraru, Costel1; Search for: Chang, Shoude1; Search for: Popescu, Dan P.2; Search for: Sowa, Michael G.2 |
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| Affiliation | - National Research Council of Canada. NRC Institute for Microstructural Sciences
- National Research Council of Canada. NRC Institute for Biodiagnostics
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| Format | Text, Article |
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| Subject | Optical coherence tomography; Quadrature interferometer; Semiconductor optical amplifier; Medical; Biological imaging |
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| Abstract | A performance analysis of signal to noise ratio for an optical coherence tomography system with quadrature detection and a semiconductor optical amplifier in the sample arm is discussed. The results are compared and discussed in relation to a conventional OCT system (without optical amplification). An increase of the signal to noise ratio up to 14 dB at a depth of 0.5 mmis obtained compared to the system without the optical amplifier. Overall, an improvement was demonstrated for signal coming from deeper regions within the samples. Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using this system. Improvement of signal to noise ratio increases the penetration depth possible for OCT images, from 1 mm to 2 mm within the vessel wall of an artery. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with this OCT system. |
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| Publication date | 2011-01-11 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 17400968 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 8d396559-d11d-4095-b70e-facc2bbe9815 |
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| Record created | 2011-03-26 |
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| Record modified | 2020-04-21 |
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