Biological antioxidants [and discussion]

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Journal titlePhilosophical transactions of the Royal Society of London. Series B: Biological sciences
Pages565578; # of pages: 14
Subjectalpha tocopherol; antioxidant; ascorbic acid; beta carotene; carotenoid; free radical; glutathione peroxidase; lipid; peroxide; phenol derivative; phospholipid; article; kinetics; lipid bilayer; metabolism; oxidation reduction reaction; Antioxidants; Ascorbic Acid; beta Carotene; Carotenoids; Free Radicals; Glutathione Peroxidase; Kinetics; Lipid Bilayers; Lipids; Oxidation-Reduction; Peroxides; Phenols; Phospholipids; Support, Non-U.S. Gov't; Vitamin E
AbstractThe mechanism of lipid peroxidation and the ways in which the rate of this reaction can be reduced by small quantities of certain specific chemicals, called antioxidants, are described. The types and roles of the different antioxidants found in living systems are considered. Vitamin E (alpha-tocopherol) has long been recognized as an important lipid-soluble, chain-breaking antioxidant. It has an unexpectedly high reactivity towards peroxyl radicals, which can be understood only after detailed consideration of its structure. It is the major antioxidant of its class in human blood and its effectiveness in plasma is greatly improved by a synergistic interaction with water-soluble reducing agents such as ascorbic acid. Experiments designed to locate vitamin E within phospholipid bilayers and to discover the origin of the different biopotencies of stereoisomers of alpha-tocopherol are also described.
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AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276529
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Record identifier6fc46331-0e66-4847-bfe3-a99158fbafa4
Record created2015-10-13
Record modified2016-05-09
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