Bioactive rosette nanotubes for bone tissue engineering and drug delivery

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TypeBook Chapter
Book titlePeptide Materials: From Nanostructures to Applications
Pages313357; # of pages: 45
Subjectrosette nanotubes; guanine-cytosine motif; self-assembly; bioactive peptides; bone tissue engineering; titanium implant materials; osteoblast; hydrogels; drug delivery
AbstractThis chapter describes novel bio-inspired nanotubular architectures called rosette nanotubes (RNTs), which are self-assembled in water from a guanine-cytosine (the G{n-ary logical and}C motif) hybrid molecule. In the first part of the chapter, the design, synthesis and chemical functionalization of RNTs with amino acid residues, peptides and other organic and inorganic moieties are highlighted. Their stability and physical properties are next examined, followed by in vivo and in vitro toxicity and biocompatibility studies. Finally, RNT applications in bone tissue engineering and in drug delivery are described. In the case of the former, this includes RNTs as 2D coatings on Ti implant materials, as well as their incorporation within currently used pHEMA hydrogels for enhanced bone cell adhesion and growth. © 2013 John Wiley & Sons, Ltd.
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AffiliationNational Research Council Canada (NRC-CNRC); Security and Disruptive Technologies
Peer reviewedYes
NPARC number21271850
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Record identifier6e065df3-8a08-467c-ba9b-280271be5cc3
Record created2014-04-24
Record modified2016-05-09
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